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Portable Oxygen Concentrators

16 products
  • Inogen One® G4® Portable Oxygen Concentrator and Inogen At Home® Stationary Oxygen Concentrator Bundle - Main Clinic Supply
    from $4,200.00
    from $4,200.00
    Out of Stock
  • Oxlife Liberty2 - True Continuous Flow Portable Oxygen - Main Clinic Supply
    from $2,995.00
    from $2,995.00
    Out of Stock
  • Inogen One® G3® Portable Oxygen Concentrator, Standard Battery - Main Clinic Supply
    from $1,995.00
    from $1,995.00
    Out of Stock
  • O2 Concepts OxLife Independence Portable Oxygen Concentrator - Main Clinic Supply
    from $3,195.00
    from $3,195.00
    Out of Stock
  • GCE Zen-O Lite Portable Oxygen Concentrator - Main Clinic Supply
    from $2,295.00
    from $2,295.00
    Out of Stock
  • GCE Zen-O Portable Oxygen Concentrator - Main Clinic Supply
    from $2,285.00
    from $2,285.00
    Out of Stock
  • Caire Eclipse 5 - Portable Oxygen Concentrator - Main Clinic Supply
    from $3,200.00
    from $3,200.00
    Out of Stock

Those with respiratory conditions who need a portable oxygen concentrator (POC) for the first time may initially feel overwhelmed by the many choices. 

While most on-the-go portable oxygen concentrators are lightweight and efficient, they can differ significantly from model to model. 

Our collection summary gives you an overview of our portable oxygen concentrator specifications. 

Best Portable Oxygen Concentrators and Machines in 2024, and a Look Into 2025

When looking for the best portable oxygen concentrator in 2024, Main Clinic Supply is excited to announce early access to the Inogen Rove 4. This highly anticipated model is now available ahead of its official 2025 release! Additionally, the Inogen One Rove 6 and the GCE Zen-O are excellent options that continue to push the boundaries of portable oxygen therapy. Here’s a breakdown of the top models, including what makes the Inogen Rove 4 so special.

Early Access: Inogen Rove 4 Portable Oxygen Concentrator

Main Clinic Supply is thrilled to offer early access to the Inogen Rove 4, a game-changing oxygen concentrator for 2025. We are among the first to make this device available, giving you the chance to experience its ultra-lightweight design and enhanced portability before anyone else.

The Inogen Rove 4 is expected to be one of the lightest portable oxygen concentrators on the market, weighing an estimated 3.5 pounds. With a projected battery life of up to 8 hours and easy-to-use features, this device is perfect for those who need both high performance and portability. Its FAA approval is pending, but it's designed to be the ultimate travel companion for oxygen therapy users. Don't wait—be among the first to experience the Inogen Rove 4!

For more details on how to order the Inogen Rove 4, click [here].

Discontinued Models: Inogen One G3, Philips SimplyGo, and SimplyGo Mini

Although the Inogen One G3, Philips SimplyGo, and SimplyGo Mini were once highly sought after, these models have now been discontinued. If you're looking for an upgrade or replacement, the latest models like the Inogen One Rove 6 and GCE Zen-O are excellent alternatives, offering superior technology, longer battery life, and improved oxygen delivery.

Portable Oxygen Concentrator Comparison Chart

Feature Inogen One Rove 6 Inogen Rove 4 (2025) GCE Zen-O
Weight 4.8 pounds 3.5 pounds 10 pounds
Sound level 38 decibels 39 decibels 42 decibels
Battery life Up to 12 hours Up to 8 hours (est.) Up to 8 hours
Flow settings 1-6 1-4 (est.) Pulse & constant flow
Size L: 8.18", W: 3.26", H: 8.15" L: 5.9 x W: 2.7 x H: 7.5 in L: 12.3", W: 8.3", H: 8.3"
Exclusive Technology Intelligent Oxygen Delivery Intelligent Oxygen Delivery Rate Responsive Therapy™ (RRT)
FAA Approved Yes Yes Yes
Power Features AC/DC power supply for worldwide use AC/DC AC/DC power supply, continuous flow

Inogen One Rove 6 Portable Oxygen Concentrator

The Inogen One Rove 6 is a highly reliable and portable oxygen concentrator, offering up to 12 hours of battery life and weighing just 4.8 pounds. Designed for active users, it features intelligent oxygen delivery, ensuring consistent oxygen flow throughout the day, making it ideal for travel and everyday use.

For users looking for a powerful, travel-friendly solution, the Inogen One Rove 6 is the top choice in 2024.

GCE Zen-O Portable Oxygen Concentrator

For those needing constant-flow oxygen, the GCE Zen-O is an exceptional option. While it’s slightly heavier at 10 pounds, its ability to deliver both pulse and constant-flow oxygen makes it ideal for users with more demanding oxygen needs. With up to 8 hours of battery life and FAA approval, the Zen-O provides versatility for both travel and home use.

Ultimate Freedom Package - Inogen One G4 Portable Oxygen Concentrator + Inogen At Home Oxygen Concentrator

If you want nighttime continuous flow oxygen with daytime portability and freedom, the Ultimate Freedom Package is ideal. 

This package includes the Inogen GS-100 - one of the market's lightest, quietest continuous-flow portable oxygen concentrators. Plus, it also comes with the highly portable Inogen One G4 for daytime convenience. 

A standard three-year warranty applies to the machines, upgradable to lifetime warranties. The package includes a travel case for the Inogen-100 and free FedEx next-day delivery.

Ultimate Freedom Package - Inogen One G5 Portable Oxygen Concentrator + Inogen At Home Oxygen Concentrator

This Ultimate Freedom Package offers you the G5 - the most advanced pulse flow portable Inogen model with the powerful and reliable continuous flow GS-100.

The G5 weighs just 4.7 pounds, including the battery, and comes with an optional backpack or carry bag. 

A complimentary travel case for the GS-100 is included; both concentrators come with a three-year warranty and optional lifetime warranty and service upgrades.

Why Choose Main Clinic Supply?

At Main Clinic Supply, we’re proud to be among the first to offer early access to the Inogen Rove 4. We specialize in providing the latest technology in portable oxygen concentrators, including exclusive access to new releases. Our range of portable oxygen concentrators caters to a variety of needs, helping our customers maintain their active lifestyles with confidence.

Explore our full collection to find the best portable oxygen concentrator for you and take advantage of early access to the Inogen Rove 4!



Main Clinic Supply, based in Rochester, Minnesota (Home of The World Famous Mayo Clinic), we deliver free to all Mayo Clinic hospitals and local hotels. With FedEx's strong presence, the family-owned business ships late into the evening.


Inspired by Mayo Clinic's values, they prioritize helping people over making profits, embodying Dr. Mayo's 1910 mission statement: "The needs of the patient come first."


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