Can an Oxygen Concentrator Make You Sick? Side Effects & Safe Use Tips
Key Takeaways
-
Oxygen concentrators can cause side effects including nasal dryness, morning headaches, fatigue, and skin irritation, but these are typically manageable with proper techniques.
-
Using an oxygen concentrator without a prescription or at incorrect flow rates can lead to serious complications like oxygen toxicity or insufficient oxygen therapy.
-
Regular cleaning and maintenance of your oxygen concentrator is essential to prevent potentially dangerous infections and equipment failures.
-
Always follow your doctor's exact prescription for oxygen flow rates and usage duration to minimize side effects and maximize benefits.
-
As both an Authorized Inogen Reseller and Service Center, Main Clinic Supply provides FDA-cleared portable oxygen concentrators (POCs), same-day repairs, next-day shipping across the U.S. and Canada, and overnight replacement options available through select Lifetime Warranty and Service Plans.
Common Side Effects of Using Oxygen Concentrators
When you begin oxygen therapy with a concentrator, your body may need time to adjust to the supplemental oxygen. During this adjustment period, you might notice several mild side effects that typically improve over time.
Most of these side effects are related to the delivery method rather than the oxygen itself. Here are some common side effects you might experience:
Nasal Dryness & Irritation
The most frequently reported side effect of oxygen therapy is nasal dryness and irritation. This happens because oxygen is delivered as a dry gas, which can dry out the delicate tissues inside your nose. This drying effect can sometimes extend to your throat and mouth, causing similar discomfort in these areas.
Morning Headaches
Some oxygen users report experiencing headaches, particularly in the morning. These headaches can occur for several reasons related to oxygen therapy.
In some cases, headaches result from changes in carbon dioxide retention as your body adjusts to supplemental oxygen. Other times, they might be caused by sinus congestion from the nasal cannula or mask, or from the pressure of headgear if you're using a CPAP machine alongside oxygen therapy.
Morning headaches can also indicate your oxygen levels dropped during sleep, which might mean your current oxygen prescription needs adjustment. If headaches persist or are severe, discuss this with your healthcare provider.
Fatigue & Tiredness
Feeling unusually tired or fatigued is another common side effect of oxygen concentrator use. This can happen for several reasons, including your body adjusting to new oxygen levels or the disturbance of sleep due to the noise of the unit or discomfort from the cannula.
If you're consistently experiencing fatigue, it could also indicate that your oxygen settings need adjustment. Too little or too much oxygen can both contribute to feelings of tiredness. This symptom should be discussed with your healthcare provider, as they may need to modify your prescription or recommend ways to improve your sleep quality while using oxygen therapy.
Skin Irritation Around Mask or Cannula
The constant contact between your skin and the oxygen delivery device, whether it's a nasal cannula or face mask, can cause irritation, redness, or even pressure sores over time. This is especially common behind the ears, across the cheeks, or around the nostrils. The plastic material of most cannulas, combined with the continuous pressure and occasional moisture, creates ideal conditions for skin irritation to develop.
Proper fitting of your oxygen delivery device is crucial to minimize this irritation. Your equipment should be secure enough to stay in place but not so tight that it causes excessive pressure on any area of skin. Consider using specialized padding or covers designed for oxygen users to protect sensitive skin areas.
|
Main Clinic Supply: Trusted Oxygen Therapy Equipment 10,000+ 5★ Reviews | A+ BBB Rating | Mayo Clinic Area Experts
The Main Clinic Supply Difference: ✓ Best price guarantee on all POCs whenever possible Trust & Experience You Need: Family-owned Rochester business featured in USA Today, AARP, and Reader's Digest. We exclusively carry FDA-cleared POCs as an Authorized Inogen Sales and Service Center. |
How to Use Your Oxygen Concentrator Safely

While most side effects of oxygen concentrators are mild and manageable, proper usage can reduce these side effects.
1. Follow Your Doctor's Prescription Exactly
One of the most critical aspects of oxygen therapy safety is adhering precisely to your doctor's prescription. Using more oxygen than prescribed won't provide additional benefits and can increase your risk of oxygen toxicity, which can damage lung tissues. Similarly, using less than prescribed means you're not getting the therapeutic benefit your body needs.
Always maintain the exact flow rate your doctor has determined is right for your condition. This flow rate is calculated based on your specific oxygen needs, blood gas measurements, and overall health status. Remember, oxygen is considered a medication, and like any medication, the dosage matters significantly.
2. Monitor Your Blood Oxygen Levels Regularly
Regular monitoring of your blood oxygen saturation using a pulse oximeter is an essential part of oxygen therapy. This simple device clips onto your finger and measures the percentage of oxygen in your blood, helping you ensure your therapy is effective and catch any potential issues before they become serious.
Your doctor will typically tell you what your target oxygen saturation range should be. For most people, maintaining a saturation above 90% is desirable, though individual targets may vary based on your specific condition. Checking your oxygen levels at different times of day and during various activities can provide valuable information about how well your therapy is working.
3. Keep Equipment Clean & Maintained
Oxygen concentrators pull in room air to separate and concentrate oxygen, which means they can also collect dust, allergens, and potential pathogens if not properly maintained. Neglected equipment can potentially introduce contaminants into your respiratory system, causing irritation or even infection. Regular cleaning significantly reduces this risk.
Following the manufacturer's cleaning instructions is essential for both safety and equipment longevity. Most concentrators require weekly filter cleaning and regular replacement of disposable filters. The nasal cannula or mask should be replaced every 2–4 weeks to prevent bacterial growth, and tubing should typically be changed every 2–3 months.
4. Place Your Concentrator in the Right Location
Oxygen concentrators need adequate airflow to function properly and prevent overheating. Position your concentrator at least 12–18 inches away from walls, furniture, curtains, or bedding that could restrict airflow or create a fire hazard.
Choose a location with minimal dust and away from extreme temperatures. Avoid placing concentrators near heat sources like radiators, space heaters, or direct sunlight. Similarly, keep the device away from areas with high humidity like bathrooms or kitchens, as moisture can damage internal components and create electrical hazards.
5. Have a Backup Power Plan
Oxygen concentrators, especially large home or stationary units, require electricity to operate and can be affected by power outages.
For safety, it’s important to have a backup power plan, such as a generator, a backup battery system, emergency portable oxygen cylinders, or arrangements with your oxygen supplier for urgent delivery. Portable oxygen concentrators (POCs) are a practical option too since they are lightweight, battery-powered, and can be used outdoors or during travel.
Register as a medical priority customer with your local utility company for faster power restoration during outages, and keep contact details for your supplier, healthcare provider, and emergency services easily accessible. Many patients maintain a small supply of portable cylinders just for emergencies.
When to Call Your Doctor About Oxygen Side Effects

While many side effects of oxygen concentrators can be managed at home with simple adjustments, certain symptoms warrant immediate medical attention.
Warning Signs of Too Much Oxygen
Though receiving too much oxygen is less common with home concentrators, it can occur if settings are incorrectly adjusted. Contact your doctor or oxygen provider immediately if you experience confusion, changes in your breathing pattern, or unexplained anxiety while using your concentrator. Never adjust your concentrator’s flow settings without explicit direction from your healthcare provider.
Signs You're Not Getting Enough Oxygen
Insufficient oxygen delivery can quickly become dangerous. Call your doctor right away if you notice bluish discoloration of your lips or fingertips (cyanosis), increased shortness of breath, or unusual drowsiness while using your concentrator. These symptoms suggest your oxygen therapy isn't effectively meeting your body's needs.
Equipment Malfunction Indicators
Oxygen concentrators are generally reliable, but like any electronic device, they can malfunction. Contact your equipment provider immediately if you notice unusual noises, excessive heat from the unit, intermittent alarms, or changes in the way your concentrator operates.
Many modern units have built-in alarm systems that alert you to problems with oxygen concentration, power issues, or flow obstructions. Never ignore these alarms, as they indicate a potential problem with your therapy. Instead of attempting to repair the unit yourself, contact your supplier for professional service to ensure your safety and the effectiveness of your treatment.
*Note: This blog is for educational purposes only and is not medical advice. Oxygen concentrators require a prescription and must be used under the oversight of a licensed medical professional. We encourage patients to research their options so they can have informed discussions with their provider.
Safe Oxygen Therapy Starts with Main Clinic Supply
At Main Clinic Supply, we're uniquely positioned as both an Authorized Inogen Reseller and Authorized Inogen Service Center, a critical distinction when managing oxygen therapy.
We understand that proper equipment function is essential for preventing side effects and ensuring effective therapy which is why we provide same-day repairs and overnight replacements, reducing the weeks-long wait typical of factory service centers. Our in-house warranty support means faster solutions precisely when you need them most.

Our family-owned Rochester, Minnesota team, located in the Mayo Clinic area, has earned thousands of five-star reviews and an A+ BBB rating for fast, caring service.
We also offer accessible financing through CareCredit, including 6 months no interest and flexible 24–48 month payment plans, making quality oxygen therapy affordable.
When you purchase from Main Clinic Supply, you own your device outright (new or certified pre-owned) unlike DME rental programs where suppliers typically retain ownership.
With next-day shipping on most systems across the U.S. and Canada, we ensure you receive your FDA-cleared POCs quickly and maintain them properly for safe, effective oxygen therapy.
Get your reliable oxygen concentrator today.
Frequently Asked Questions (FAQs)
Can using an oxygen concentrator cause headaches?
Yes, oxygen concentrators may cause headaches, particularly in the morning. These headaches may result from your body adjusting to different oxygen concentrations, changes in blood carbon dioxide levels, or sinus congestion from the nasal cannula.
Morning headaches can also indicate your oxygen levels dropped during sleep, suggesting your prescription may need adjustment.
How can I prevent nasal dryness from my oxygen concentrator?
Nasal dryness is the most common oxygen concentrator side effect and can be managed through several techniques. First, attach a humidifier bottle to your concentrator to add moisture to the oxygen flow.
Apply water-based nasal lubricants as recommended by your doctor to protect nasal tissues. Stay well-hydrated by drinking plenty of water throughout the day, and consider using a room humidifier in your bedroom, especially during dry seasons.
Is it dangerous to use more oxygen than prescribed?
Yes, using more oxygen than prescribed is dangerous and can lead to oxygen toxicity, a serious condition that damages lung tissues.
Symptoms include persistent coughing, chest discomfort, shortness of breath, confusion, and visual disturbances. Oxygen is a medication with specific dosing requirements; more is not better.
Why should I choose Main Clinic Supply for my oxygen concentrator needs?
Main Clinic Supply offers unmatched advantages as both an Authorized Inogen Reseller and Authorized Inogen Service Center. When equipment issues or side effects arise from malfunctioning devices, we provide fast, in-house service and genuine Inogen parts, reducing the weeks-long wait typical of factory service centers. For customers enrolled in our Lifetime Warranty and Service Plans, overnight replacement options are available to minimize downtime and keep therapy uninterrupted.
Additionally, we provide next-day shipping on most FDA-cleared POCs throughout the U.S. and Canada. We carry Inogen POCs, including the Inogen One Rove 6 and Inogen One Rove 4, which are FDA-cleared, FAA-approved models designed for reliable home and travel use.
*Note: Pricing and product availability mentioned in this post are subject to change. Please check the website for current pricing and stock information before making a purchase.

